Tg(Wap-cre)51Nki
Transgene Detail

Summary

• Symbol: Tg(Wap-cre)51Nki
• Name: transgene insertion 51, The Netherlands Cancer Institute
• MGI ID: MGI:3801314
• Synonyms: Wcre
• Transgene: Tg(Wap-cre)51Nki Location: unknown
• Alliance: Tg(Wap-cre)51Nki page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Wap-cre)51Nki expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Wap (MGI:98943)

• Mutation details: The transgene consists of a 4.5 kb genomic fragment of the mouse whey acidic protein promoter (Wap) followed by a rabbit beta-globin intron, cre coding sequence, and a transcription termination/polyadenylation fragment from the human growth hormone gene. The purified 7.8 kb fragment was microinjected into one-cell stage embryos from FVB/N mice. This is a high expressing line (51). (J:171765)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Wap (mouse) Summary of all recombinase alleles driven by Wap. Alliance mouse Wap gene page

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(Wap-cre)51Nki

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:171765 Derksen PW, et al., Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice. Dis Model Mech. 2011 May-Jun;4(3):347-58
• All: 14 reference(s)