Zfpm2^tm2Sho
Targeted Allele Detail

Summary

• Symbol: Zfpm2^tm2Sho
• Name: zinc finger protein, multitype 2; targeted mutation 2, Stuart Orkin
• MGI ID: MGI:3802480
• Synonyms: Fog2^flox
• Gene: Zfpm2 Location: Chr15:40518438-40967988 bp, + strand Genetic Position: Chr15, 15.74 cM, cytoband C
• Alliance: Zfpm2^tm2Sho page

Abnormal heart development and coronary vasculogenesis in Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Zfpm2^tm1Sho/Zfpm2^tm2Sho mice

Show the 7 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120985
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into the 7th intron and a second loxP site was inserted into the XbaI site of the 3' downstream sequence. (J:120985)

Expression

In Mice Carrying this Mutation:	13 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zfpm2 Mutation: 47 strains or lines available

References

• Original: J:120985 Manuylov NL, et al., Fog2 excision in mice leads to premature mammary gland involution and reduced Esr1 gene expression. Oncogene. 2007 Aug 9;26(36):5204-13
• All: 7 reference(s)