Ppargc1b^tm1.1Dpk
Targeted Allele Detail

Summary

• Symbol: Ppargc1b^tm1.1Dpk
• Name: peroxisome proliferative activated receptor, gamma, coactivator 1 beta; targeted mutation 1.1, Daniel P Kelly
• MGI ID: MGI:3802519
• Synonyms: PGC-1beta^-
• Gene: Ppargc1b Location: Chr18:61431207-61533502 bp, - strand Genetic Position: Chr18, 34.41 cM
• Alliance: Ppargc1b^tm1.1Dpk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137598
• Parent Cell Line: SCC10 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre-mediated recombination was used to remove exons 4 through 6. Removal of these exons results in a frame shift and a premature STOP codon in exon 7. The absence of protein product was confirmed by western blot analysis on heart extracts. (J:137598)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ppargc1b Mutation: 57 strains or lines available

References

• Original: J:137598 Lai L, et al., Transcriptional coactivators PGC-1{alpha} and PGC-l{beta} control overlapping programs required for perinatal maturation of the heart. Genes Dev. 2008 Jul 15;22(14):1948-61
• All: 5 reference(s)