Slc35d3^IAP
Spontaneous Allele Detail

Summary

• Symbol: Slc35d3^IAP
• Name: solute carrier family 35, member D3; intracisternal A particle insertion
• MGI ID: MGI:3802578
• Synonyms: Roswell, Slc35d3^-, Slc35d3^ros
• Gene: Slc35d3 Location: Chr10:19723662-19727205 bp, - strand Genetic Position: Chr10, 9.12 cM, cytoband A2
• Alliance: Slc35d3^IAP page

Mutation origin

• Strain of Origin: C3H/HeSn-Rab27a^ash/JRos

Mutation description

• Allele Type: Spontaneous
• Mutations: Insertion, Intragenic deletion
• Mutation details: 468 bp of endogenous sequence in exon 1 was replaced with a 39 bp intracisternal A particle (IAP) sequence resulting in a new translation initiation methionine codon and substitution of 7 new amino acids for 10 endogenous amino acids at the N-terminus (MRQLCRGRVL becomes MWGRLPT). No gain of function effect is observed as in other spontaneous mutations derived from IAP insertion. (J:137593)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc35d3 Mutation: 12 strains or lines available

References

• Original: J:137593 Chintala S, et al., The Slc35d3 gene, encoding an orphan nucleotide sugar transporter, regulates platelet-dense granules. Blood. 2007 Feb 15;109(4):1533-40
• All: 4 reference(s)