Glra1^cincinnati
Spontaneous Allele Detail

Summary

• Symbol: Glra1^cincinnati
• Name: glycine receptor, alpha 1 subunit; cincinnati
• MGI ID: MGI:3802579
• Synonyms: Glra1^dup5
• Gene: Glra1 Location: Chr11:55405065-55499024 bp, - strand Genetic Position: Chr11, 33.12 cM
• Alliance: Glra1^cincinnati page

Mutation origin

• Strain of Origin: B6.129S6-Acadl^tm1Uab/Mmmh

Mutation description

• Allele Type: Spontaneous
• Mutation: Duplication
• Glra1^cincinnati involves 1 genes/genome features (Glra1) View all
• Mutation details: A tandem duplication containing the last 279 bp of intron 4, all 83 bp of exon 5 and the first 175 bp of intron 5 created a premature stop codon at the junction between the two copies of exon 5 (F187X). The predicted protein product lacks the 262 residues from the C-terminus of the 449 residuefull-length protein. (J:137595)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Glra1 Mutation: 30 strains or lines available

References

• Original: J:137595 Holland KD, et al., De novo exon duplication in a new allele of mouse Glra1 (spasmodic). Genetics. 2006 Dec;174(4):2245-7
• All: 2 reference(s)