Tk2^tm1Anka
Targeted Allele Detail

Summary

• Symbol: Tk2^tm1Anka
• Name: thymidine kinase 2, mitochondrial; targeted mutation 1, Anna Karlsson
• MGI ID: MGI:3802583
• Gene: Tk2 Location: Chr8:104953317-104975190 bp, - strand Genetic Position: Chr8, 53.04 cM
• Alliance: Tk2^tm1Anka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137664
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 4 and 5 were replaced with a neo cassette. (J:137664)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tk2 Mutation: 19 strains or lines available

References

• Original: J:137664 Zhou X, et al., Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice. Hum Mol Genet. 2008 Aug 1;17(15):2329-35
• All: 7 reference(s)