Crem^tm1.1Endo
Targeted Allele Detail

Summary

• Symbol: Crem^tm1.1Endo
• Name: cAMP responsive element modulator; targeted mutation 1.1, Shogo Endo
• MGI ID: MGI:3802585
• Gene: Crem Location: Chr18:3266048-3337748 bp, - strand Genetic Position: Chr18, 2.14 cM, cytoband A
• Alliance: Crem^tm1.1Endo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137666
• Parent Cell Line: MS12 (ES Cell)
• Strain of Origin: C57BL/6NSlc

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon P2 and a neo cassette with a 3' loxP site was inserted downstream of exon P2. Transient cre expression in fertilized oocytes was used to remove the neo cassette and exon P2. (J:137666)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Crem Mutation: 40 strains or lines available

References

• Original: J:137666 Kojima N, et al., Inducible cAMP early repressor acts as a negative regulator for kindling epileptogenesis and long-term fear memory. J Neurosci. 2008 Jun 18;28(25):6459-72
• All: 4 reference(s)