Twsg1^tm1Ecan
Targeted Allele Detail

Summary

• Symbol: Twsg1^tm1Ecan
• Name: twisted gastrulation BMP signaling modulator 1; targeted mutation 1, Ernesto Canalis
• MGI ID: MGI:3802605
• Synonyms: Twsg1^LacZ
• Gene: Twsg1 Location: Chr17:66230060-66258198 bp, - strand Genetic Position: Chr17, 35.26 cM
• Alliance: Twsg1^tm1Ecan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137597
• Parent Cell Line: F1H4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced with a lacZ and floxed neo cassette. The absence of transcript was confirmed by northern blot analysis of 4 week old total RNA extracts. (J:137597)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Twsg1 Mutation: 20 strains or lines available

References

• Original: J:137597 Gazzerro E, et al., Twisted gastrulation, a bone morphogenetic protein agonist/antagonist, is not required for post-natal skeletal function. Bone. 2006 Dec;39(6):1252-60
• All: 4 reference(s)