Rr149356^tm1Abnd
Targeted Allele Detail

Summary

• Symbol: Rr149356^tm1Abnd
• Name: regulatory region 149356; targeted mutation 1, Antonio Bernad
• MGI ID: MGI:3802614
• Synonyms: deltaEbeta-six-neo-six
• Gene: Rr149356 Location: Chr6:41526801-41532817 bp Genetic Position: Chr6, Syntenic
• Alliance: Rr149356^tm1Abnd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137580
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The enchancer (Ebeta) was replaced with a six-flanked neo cassette. Six sequences are targeted for recombination by beta-recombinase. (J:137580)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Rr149356^tm1Abnd/Rr149356^tm1Abnd	involves: 129S1/Sv * 129X1/SvJ

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
endocrine/exocrine glands	√
abnormal thymus morphology	√
thymus hypoplasia	√
hematopoietic system	√
abnormal thymus morphology	√
thymus hypoplasia	√
abnormal T cell differentiation	√
increased double-negative T cell number	√
arrested T cell differentiation	√
increased gamma-delta T cell number	√
decreased T cell number	√
decreased double-positive T cell number	√
decreased single-positive T cell number	√
immune system	√
abnormal thymus morphology	√
thymus hypoplasia	√
abnormal T cell differentiation	√
increased double-negative T cell number	√
decreased double-positive T cell number	√
arrested T cell differentiation	√
increased gamma-delta T cell number	√
decreased T cell number	√
decreased single-positive T cell number	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr149356 Mutation: 0 strains or lines available

References

• Original: J:137580 Servert P, et al., In vivo site-specific recombination using the beta-rec/six system. Biotechniques. 2008 Jul;45(1):69-78
• All: 1 reference(s)