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Tg(IGK@yK1)9.2CJkbv
Transgene Detail
Summary
Symbol: Tg(IGK@yK1)9.2CJkbv
Name: transgene insertion 9.2C, Aya Jakobovits
MGI ID: MGI:3802658
Synonyms: HuAb-kappa, Tg(IGKyK1)9.2CJkbv, yK1
Transgene: Tg(IGK@yK1)9.2CJkbv  Location: unknown  
Alliance: Tg(IGK@yK1)9.2CJkbv page
Transgene
origin
Germline Transmission:  Earliest citation of germline transmission: J:23827
Parent Cell Line:  E14.1TG3B1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(IGK@yK1)9.2CJkbv expresses 1 gene
 
Mutation detailsA yeast artificial chromosome was constructed with a 170-kb insert of the human IgK locus. This insert contained in germline configuration the kappa deleting element, the intronic and downstream enhancers, all five functional J-k regions, and the three most proximal variable gene segments. An HPRT mini-gene was included downstream of the constant regions to aid targeting. Line 9.2C had one copy of the YAC intergrate into the mouse genome and was one of at least 8 lines generated. Southern blotting confirmed that the YAC integrated without any recombination events occurring. (J:23827)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:23827 Green LL, et al., Antigen-specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs. Nat Genet. 1994 May;7(1):13-21
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory