Tg(IGH@*)SALed
Transgene Detail

Summary

• Symbol: Tg(IGH@*)SALed
• Name: transgene insertion SA, Philip Leder
• MGI ID: MGI:3802806
• Synonyms: human mIgM, TG SA
• Transgene: Tg(IGH@*)SALed Location: unknown
• Alliance: Tg(IGH@*)SALed page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(IGH@*)SALed expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IGHM (3507)

  Ighm	(MGI:96448)

• Mutation details: A recombined human mu heavy chain immunoglobulin gene was used in the construction of a transgene. Downstream of the last mu constant region exon, two deletions eliminated the cleavage /poly(A) addition signal so that only the membrane bound form IgM would be expressed. Two transgene lines were created, SA and SD, with the SA line having higher expression. Transgene expression was detected by RT-PCR in the spleen and brain of both transgenic lines. (J:131938)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:131938 Nussenzweig MC, et al., Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin mu. Science. 1987 May 15;236(4803):816-9
• All: 8 reference(s)