Dclre1c^tm1.1Jpdv
Targeted Allele Detail

Summary

• Symbol: Dclre1c^tm1.1Jpdv
• Name: DNA cross-link repair 1C; targeted mutation 1.1, Jean-Pierre de Villartay
• MGI ID: MGI:3802969
• Synonyms: Art^-, Artemis^-
• Gene: Dclre1c Location: Chr2:3425168-3465167 bp, + strand Genetic Position: Chr2, 1.93 cM
• Alliance: Dclre1c^tm1.1Jpdv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137712
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P1/ReJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 12 and a floxed neo cassette was inserted downstream of exon 12. Transient cre expression in ES cells resulted in removal of exon 12 and the neo cassette. The expression of a truncated transcript was confirmed by RT-PCR analysis. (J:137743)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dclre1c Mutation: 31 strains or lines available

References

• Original: J:137712 Touvrey C, et al., Distinct effects of DNA-PKcs and Artemis inactivation on signal joint formation in vivo. Mol Immunol. 2008 Jul;45(12):3383-91
• All: 3 reference(s)