Sostdc1^tm1Noit
Targeted Allele Detail

Summary

• Symbol: Sostdc1^tm1Noit
• Name: sclerostin domain containing 1; targeted mutation 1, Nobue Itasaki
• MGI ID: MGI:3802970
• Synonyms: Wise^-
• Gene: Sostdc1 Location: Chr12:36364168-36368451 bp, + strand Genetic Position: Chr12, 16.82 cM, cytoband B2
• Alliance: Sostdc1^tm1Noit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137689
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The sequence in exon 1 following the translation initiation codon were replaced with an AFP and floxed neo cassette. The targeted mutation occurs in the C57BL/6 chromosome. (J:137689)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sostdc1 Mutation: 28 strains or lines available

References

• Original: J:137689 Shigetani Y, et al., Wise promotes coalescence of cells of neural crest and placode origins in the trigeminal region during head development. Dev Biol. 2008 Jul 15;319(2):346-58
• All: 1 reference(s)