Tg(Myh6-cre/PGR*)1Mds
Transgene Detail

Summary

• Symbol: Tg(Myh6-cre/PGR*)1Mds
• Name: transgene insertion 1, Michael D Schneider
• MGI ID: MGI:3803295
• Synonyms: alphaMHC-CrePR1, line 6299, MHC-Cre
• Transgene: Tg(Myh6-cre/PGR*)1Mds Location: unknown
• Alliance: Tg(Myh6-cre/PGR*)1Mds page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: mifepristone
• Mutation: Insertion
• Tg(Myh6-cre/PGR*)1Mds expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Myh6

• Mutation details: The Myh6 promoter was used to drive cardiac myocyte-specific expression of an inducible cre fused to the mutated ligand-binding domain of human PGR (amino acids 641-891). Three founder lines, 6306, 6297, and 6299, were generated with line 6306 showing the lowest level of cre protein by Western blot and lowest prevalence of ligand-dependent recombination, with 6299 showing the highest level of recombination. Copy number was found to be highest in 6299 (about 10) with 6306 having the lowest (1). (J:127215)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Myh6 (species not specified) Summary of all recombinase alleles driven by Myh6. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:127215 Minamino T, et al., Inducible gene targeting in postnatal myocardium by cardiac-specific expression of a hormone-activated Cre fusion protein. Circ Res. 2001 Mar 30;88(6):587-92
• All: 7 reference(s)