Frzb^tm1Nat
Targeted Allele Detail

Summary

• Symbol: Frzb^tm1Nat
• Name: frizzled-related protein; targeted mutation 1, Jeremy Nathans
• MGI ID: MGI:3803336
• Synonyms: sFRP3 KO
• Gene: Frzb Location: Chr2:80242314-80277740 bp, - strand Genetic Position: Chr2, 48.13 cM
• Alliance: Frzb^tm1Nat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137890
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first coding exon of the gene, coding for the cysteine rich domain, was replaced with the bacterial beta-Gal reporter gene and the PGKneo selectable marker, both in the plus orientation. (J:137890)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Frzb Mutation: 23 strains or lines available

References

• Original: J:137890 Nathans J, Generation of an Frzb mutant allele. MGI Direct Data Submission. 2008
• All: 4 reference(s)