Del(10Prtn3-Elane)1Deje
Targeted Allele Detail

Summary

• Symbol: Del(10Prtn3-Elane)1Deje
• Name: Deletion, Chr 10, Dieter E Jenne 1
• MGI ID: MGI:3803339
• Synonyms: Del1Deje, Ela2/Prtn3^tm1Deje, Elane/Prtn3^tm1Deje, Prtn3^-Ela2^-
• Gene: Del(10Prtn3-Elane)1Deje Location: unknown Genetic Position: Chr10, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137674
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(10Prtn3-Elane)1Deje involves 2 genes/genome features (Prtn3, Elane) View all
• Mutation details: Exons 2 through 5 of Prtn3 and exons 1 through 3 of Elane were replaced with a floxed neo cassette. The neo cassette was removed by transient expression of cre in ES cells. The absence of transcript from either gene was confirmed by RT-PCR on bone marrow extracts. (J:137674)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(10Prtn3-Elane)1Deje Mutation: 0 strains or lines available

References

• Original: J:137674 Kessenbrock K, et al., Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin. J Clin Invest. 2008 Jul;118(7):2438-47
• All: 8 reference(s)