Trpm2^tm1Yamo
Targeted Allele Detail

Summary

• Symbol: Trpm2^tm1Yamo
• Name: transient receptor potential cation channel, subfamily M, member 2; targeted mutation 1, Yasuo Mori
• MGI ID: MGI:3803341
• Gene: Trpm2 Location: Chr10:77743556-77805746 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Trpm2^tm1Yamo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137676
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The third coding exon was replaced with a neo cassette. The absence of transcript was confirmed by northern blot analysis on brain extracts. (J:137676)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpm2 Mutation: 112 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Major Affective Disorder J:226171.

References

• Original: J:137676 Yamamoto S, et al., TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nat Med. 2008 Jul;14(7):738-47
• All: 52 reference(s)