Gt(ROSA)26Sor^tm2(Pax3)Joe
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm2(Pax3)Joe
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Jonathan A Epstein
• MGI ID: MGI:3803568
• Synonyms: R26^Pax3, Rosa26-loxP-stop-loxP-Pax3-cDNA, ROSA^Pax3
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm2(Pax3)Joe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137730
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^tm2(Pax3)Joe expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Pax3 (MGI:97487)

• Mutation details: A murine Pax3 cDNA preceded by a floxed neo and STOP cassette was inserted into the ROSA locus. Expression of Pax3 can only be achieve by cre-mediated recombination to remove the neo/STOP cassette. (J:137730)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 992 strains or lines available

References

• Original: J:137730 Wu M, et al., Persistent expression of Pax3 in the neural crest causes cleft palate and defective osteogenesis in mice. J Clin Invest. 2008 Jun;118(6):2076-87
• All: 2 reference(s)