Hras^tm1Xbr
Targeted Allele Detail

Summary

• Symbol: Hras^tm1Xbr
• Name: Harvey rat sarcoma virus oncogene; targeted mutation 1, Xose R Bustelo
• MGI ID: MGI:3803581
• Synonyms: H-Ras^geo
• Gene: Hras Location: Chr7:140770839-140773938 bp, - strand Genetic Position: Chr7, 86.48 cM
• Alliance: Hras^tm1Xbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137729
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: An IRES-beta-geo cassette was knocked into coding exon 4 at a position 263 bp downstream of the translation termination codon. (J:137729)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hras Mutation: 30 strains or lines available

References

• Original: J:137729 Schuhmacher AJ, et al., A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition. J Clin Invest. 2008 Jun;118(6):2169-79
• All: 2 reference(s)