Tcf3^tm1Mbu
Targeted Allele Detail

Summary

• Symbol: Tcf3^tm1Mbu
• Name: transcription factor 3; targeted mutation 1, Meinrad Busslinger
• MGI ID: MGI:3803637
• Synonyms: Tcfe2a^fl
• Gene: Tcf3 Location: Chr10:80245348-80269481 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Tcf3^tm1Mbu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137719
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 17 and an frt-flanked GFP-neo cassette with a 5' loxP site and 6 poly-adenylation sequences was inserted downstream of exon 19. (J:137719)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tcf3 Mutation: 43 strains or lines available

References

• Original: J:137719 Kwon K, et al., Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development. Immunity. 2008 Jun;28(6):751-62
• All: 7 reference(s)