Tcf3^tm1.2Mbu
Targeted Allele Detail

Summary

• Symbol: Tcf3^tm1.2Mbu
• Name: transcription factor 3; targeted mutation 1.2, Meinrad Busslinger
• MGI ID: MGI:3803639
• Synonyms: Tcfe2a^delta
• Gene: Tcf3 Location: Chr10:80245348-80269481 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Tcf3^tm1.2Mbu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137719
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, flp-mediated recombination of Tcfe2a^tm1.1Mbu was used to remove the GFP-neo cassette. This allele lacks exons 17 through 19 and contains no GFP expression cassette. (J:137719)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf3 Mutation: 43 strains or lines available

References

• Original: J:137719 Kwon K, et al., Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development. Immunity. 2008 Jun;28(6):751-62
• All: 1 reference(s)