Hand2^tm1.1Majh
Targeted Allele Detail

Summary

• Symbol: Hand2^tm1.1Majh
• Name: heart and neural crest derivatives expressed 2; targeted mutation 1.1, Marthe J Howard
• MGI ID: MGI:3803647
• Synonyms: Hand2^ploxp
• Gene: Hand2 Location: Chr8:57774018-57777552 bp, + strand Genetic Position: Chr8, 29.8 cM
• Alliance: Hand2^tm1.1Majh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138032
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and a floxed neo cassette was inserted downstream of exon 1. Germ line, cre-mediated recombination was used to remove the neo cassette leaving exon 1 floxed. (J:138032)

Expression

In Mice Carrying this Mutation:	8 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hand2 Mutation: 12 strains or lines available

References

• Original: J:138032 Hendershot TJ, et al., Expression of Hand2 is sufficient for neurogenesis and cell type-specific gene expression in the enteric nervous system. Dev Dyn. 2007 Jan;236(1):93-105
• All: 8 reference(s)