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Fasldel1Hong
Spontaneous Allele Detail
Summary
Symbol: Fasldel1Hong
Name: Fas ligand; deletion 1, Wanjin Hong
MGI ID: MGI:3803664
Synonyms: FasLdel
Gene: Fasl  Location: Chr1:161608260-161616064 bp, - strand  Genetic Position: Chr1, 69.95 cM
Alliance: Fasldel1Hong page
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
 
Mutation detailsA spontaneous mutation results in the small deletion of 5 nucleotides at the 5' end of the first intron, removing the invariant GT dinucleotide in the 5' splice consensus sequence. Splicing between the first and second exons is aberrant, generating non-functional polypeptides and creating a loss-of-function allele. (J:112563)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fasl Mutation:  37 strains or lines available
References
Original:  J:112563 Wang CC, et al., Mouse lymphomas caused by an intron-splicing donor site deletion of the FasL gene. Biochem Biophys Res Commun. 2006 Oct 13;349(1):50-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory