Cited2^tm2Bha
Targeted Allele Detail

Summary

• Symbol: Cited2^tm2Bha
• Name: Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2; targeted mutation 2, Shoumo Bhattacharya
• MGI ID: MGI:3803778
• Synonyms: Cited2^floxed
• Gene: Cited2 Location: Chr10:17598966-17601422 bp, + strand Genetic Position: Chr10, 7.18 cM, cytoband A2
• Alliance: Cited2^tm2Bha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137951
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2, which contains the entire open reading frame, and an frt-flanked neo cassette with a 5' loxP site followed by a lacZ cassette was inserted downstream of exon 2. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exon 2 floxed and the lacZ cassette intact. (J:137951)

Expression

In Structures Affected by this Mutation:

18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cited2 Mutation: 23 strains or lines available

References

• Original: J:137951 MacDonald ST, et al., Epiblastic Cited2 deficiency results in cardiac phenotypic heterogeneity and provides a mechanism for haploinsufficiency. Cardiovasc Res. 2008 Aug 1;79(3):448-57
• All: 3 reference(s)