Itgb4^tm1Mfel
Targeted Allele Detail

Summary

• Symbol: Itgb4^tm1Mfel
• Name: integrin beta 4; targeted mutation 1, Maria Laura Feltri
• MGI ID: MGI:3803792
• Synonyms: beta4^F
• Gene: Itgb4 Location: Chr11:115865556-115899238 bp, + strand Genetic Position: Chr11, 80.91 cM
• Alliance: Itgb4^tm1Mfel page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137852
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 3' loxP site was inserted upstream of exon 2 and an additional loxP site was inserted downstream of exon 2. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exon 2 floxed. (J:137852)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgb4 Mutation: 107 strains or lines available

References

• Original: J:137852 Nodari A, et al., Alpha6beta4 integrin and dystroglycan cooperate to stabilize the myelin sheath. J Neurosci. 2008 Jun 25;28(26):6714-9
• All: 6 reference(s)