Rela^tm1Mpa
Targeted Allele Detail

Summary

• Symbol: Rela^tm1Mpa
• Name: v-rel reticuloendotheliosis viral oncogene homolog A (avian); targeted mutation 1, Manolis Pasparakis
• MGI ID: MGI:3803795
• Synonyms: p65FL
• Gene: Rela Location: Chr19:5687511-5698158 bp, + strand Genetic Position: Chr19, 4.34 cM, cytoband B1-3
• Alliance: Rela^tm1Mpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137861
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 5' loxP site was inserted downstream of exon 1 and an additional loxP site was inserted downstream of exon 4. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exons 2 through 4 floxed. (J:137861)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rela Mutation: 28 strains or lines available

References

• Original: J:137861 Luedde T, et al., IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9733-8
• All: 6 reference(s)