Tg(Lck-Akt1*E40K)E-3Pnt
Transgene Detail

Summary

• Symbol: Tg(Lck-Akt1*E40K)E-3Pnt
• Name: transgene insertion E-3, Philip N Tsichlis
• MGI ID: MGI:3803797
• Synonyms: AktE40K
• Transgene: Tg(Lck-Akt1*E40K)E-3Pnt Location: unknown
• Alliance: Tg(Lck-Akt1*E40K)E-3Pnt page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A transgene encoding a constitutively active form of Akt1 that is tagged with a hemagluttin epitope was put under the control of the Lck promoter. Transgene expression was detected in the thymus. This line had the higher expression of the transgene of two lines described. (J:73487)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:73487 Malstrom S, et al., Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14967-72
• All: 3 reference(s)