Tg(Lck-Akt1*)M-1Pnt
Transgene Detail

Summary

• Symbol: Tg(Lck-Akt1*)M-1Pnt
• Name: transgene insertion M-1, Philip N Tsichlis
• MGI ID: MGI:3803798
• Synonyms: MyrAkt, MyrAkt1
• Transgene: Tg(Lck-Akt1*)M-1Pnt Location: unknown
• Alliance: Tg(Lck-Akt1*)M-1Pnt page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H/He)F2

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A transgene encoding a form of Akt1 that includes a Src-derived myristoylation signal and a hemagluttinin epitope tag was put under the control of the Lck promoter. Myristoylation of Akt1 causes it to be constitutively active. Transgene expression was detected in the thymus. This line had moderate expression of the transgene compared to one lower expressing line and one higher expressing line that was subsequently loss to thymic lymphomas. (J:73487)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:73487 Malstrom S, et al., Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14967-72
• All: 2 reference(s)