Fli1^tm1.1Dkw
Targeted Allele Detail

Summary

• Symbol: Fli1^tm1.1Dkw
• Name: Friend leukemia integration 1; targeted mutation 1.1, Dennis K Watson
• MGI ID: MGI:3803949
• Synonyms: Fli-1^deltaCTA
• Gene: Fli1 Location: Chr9:32333500-32454157 bp, - strand Genetic Position: Chr9, 17.74 cM
• Alliance: Fli1^tm1.1Dkw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137876
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted into exon 9 via homologous recombination resulting in a premature stop codon between the DNA-binding domain and the CTA domain. The neo cassette was removed by germ line, cre-mediated recombination. Removal of the C-terminal domain results in a 40% to 50% reduction in transcriptional activation activity and the production of a truncated protein. (J:137876)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fli1 Mutation: 26 strains or lines available

References

• Original: J:137876 Zhang XK, et al., The transcription factor Fli-1 modulates marginal zone and follicular B cell development in mice. J Immunol. 2008 Aug 1;181(3):1644-54
• All: 6 reference(s)