Mapk1^tm1Gela
Targeted Allele Detail

Summary

• Symbol: Mapk1^tm1Gela
• Name: mitogen-activated protein kinase 1; targeted mutation 1, Gary E Landreth
• MGI ID: MGI:3803954
• Synonyms: ERK2^fl, Mapk1^flox
• Gene: Mapk1 Location: Chr16:16801246-16865317 bp, + strand Genetic Position: Chr16, 10.53 cM
• Alliance: Mapk1^tm1Gela page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137882
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 2 and an additional loxP site was inserted downstream of exon 2. Transient cre transfection into ES cells was used to remove the neo cassette leaving exon 2 floxed. (J:137882)

Disease models

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mapk1^tm1Gela

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mapk1 Mutation: 43 strains or lines available

References

• Original: J:137882 Samuels IS, et al., Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function. J Neurosci. 2008 Jul 2;28(27):6983-95
• All: 41 reference(s)