Erg^mld2
Chemically induced Allele Detail

Summary

• Symbol: Erg^mld2
• Name: ETS transcription factor; multilineage defect 2
• MGI ID: MGI:3803955
• Gene: Erg Location: Chr16:95160028-95387452 bp, - strand Genetic Position: Chr16, 56.04 cM
• Alliance: Erg^mld2 page

Mutation origin

• Strain of Origin: B6.129S1-Mpl^tm1Wsa

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a thymidine to cystosine transition that resulted in an amino acid substitution of proline for serine at position 329 (S329P). This amino acid substitution reduces the transactivation activity of the protein. (J:137835)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erg Mutation: 27 strains or lines available

References

• Original: J:137835 Loughran SJ, et al., The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells. Nat Immunol. 2008 Jul;9(7):810-9
• All: 8 reference(s)