Laptm5^tm1Jow
Targeted Allele Detail

Summary

• Symbol: Laptm5^tm1Jow
• Name: lysosomal-associated protein transmembrane 5; targeted mutation 1, Jiyang O-Wang
• MGI ID: MGI:3803960
• Gene: Laptm5 Location: Chr4:130640627-130663459 bp, + strand Genetic Position: Chr4, 64.0 cM
• Alliance: Laptm5^tm1Jow page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137841
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1, that contains the transcription initiation codon, was replaced by a floxed neo cassette. The absence of protein product was confirmed by immunohistochemistry and western blot analysis. (J:137841)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Laptm5 Mutation: 35 strains or lines available

References

• Original: J:137841 Ouchida R, et al., A lysosomal protein negatively regulates surface T cell antigen receptor expression by promoting CD3zeta-chain degradation. Immunity. 2008 Jul;29(1):33-43
• All: 6 reference(s)