Irs1^tm2Tka
Targeted Allele Detail

Summary

• Symbol: Irs1^tm2Tka
• Name: insulin receptor substrate 1; targeted mutation 2, Takashi Kadowaki
• MGI ID: MGI:3803974
• Synonyms: Irs1^lox
• Gene: Irs1 Location: Chr1:82210822-82269137 bp, - strand Genetic Position: Chr1, 42.0 cM, cytoband C5
• Alliance: Irs1^tm2Tka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137846
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the gene and a floxed neo cassette was inserted downstream of the gene. (J:137846)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irs1 Mutation: 52 strains or lines available

References

• Original: J:137846 Kubota N, et al., Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding. Cell Metab. 2008 Jul;8(1):49-64
• All: 5 reference(s)