F3^tm1Nmk
Targeted Allele Detail

Summary

• Symbol: F3^tm1Nmk
• Name: coagulation factor III; targeted mutation 1, Nigel Mackman
• MGI ID: MGI:3803978
• Synonyms: TF^flox
• Gene: F3 Location: Chr3:121517186-121528697 bp, + strand Genetic Position: Chr3, 52.94 cM
• Alliance: F3^tm1Nmk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137921
• Parent Cell Line: CMTI-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and an frt-flanked neo cassette with a 5' loxP site was inserted downstream of exon 1. Germ line, flp-mediated reombination was used to remove the neo cassette leaving exon 1 floxed. (J:137921)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any F3 Mutation: 24 strains or lines available

References

• Original: J:137921 Pawlinski R, et al., Role of cardiac myocyte tissue factor in heart hemostasis. J Thromb Haemost. 2007 Aug;5(8):1693-700
• All: 24 reference(s)