Rdh1^tm1.1Jln
Targeted Allele Detail

Summary

• Symbol: Rdh1^tm1.1Jln
• Name: retinol dehydrogenase 1 (all trans); targeted mutation 1.1, Joseph Napoli
• MGI ID: MGI:3804065
• Gene: Rdh1 Location: Chr10:127595595-127604168 bp, + strand Genetic Position: Chr10, 75.21 cM, cytoband D3
• Alliance: Rdh1^tm1.1Jln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134843
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1 and a floxed neo cassette was inserted downstream of exon 1. Transient cre expression in ES cells was used to remove the neo cassette and exon 1. The absence of transcript expression was confirmed by RT-PCR analysis on liver, kidney and testis extracts. (J:134843)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rdh1 Mutation: 18 strains or lines available

References

• Original: J:134843 Zhang M, et al., Altered vitamin A homeostasis and increased size and adiposity in the rdh1-null mouse. FASEB J. 2007 Sep;21(11):2886-96
• All: 1 reference(s)