Hand2^tm1Majh
Targeted Allele Detail

Summary

• Symbol: Hand2^tm1Majh
• Name: heart and neural crest derivatives expressed 2; targeted mutation 1, Marthe J Howard
• MGI ID: MGI:3804207
• Synonyms: Hand2^flneo, Hand2^loxpneop
• Gene: Hand2 Location: Chr8:57774018-57777552 bp, + strand Genetic Position: Chr8, 29.8 cM
• Alliance: Hand2^tm1Majh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138032
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and a floxed neo cassette was inserted downstream of exon 1. Quanitative RT-PCR analysis of jaws from E11 embryos indicated that transcript expression in homozygous embryos was only about 14% that of wild-type littermates. Therefore, this allele is a hypomorph. (J:137726, J:138032)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hand2 Mutation: 12 strains or lines available

References

• Original: J:138032 Hendershot TJ, et al., Expression of Hand2 is sufficient for neurogenesis and cell type-specific gene expression in the enteric nervous system. Dev Dyn. 2007 Jan;236(1):93-105
• All: 3 reference(s)