Sox12^tm1.1Weg
Targeted Allele Detail

Summary

• Symbol: Sox12^tm1.1Weg
• Name: SRY (sex determining region Y)-box 12; targeted mutation 1.1, Michael Wegner
• MGI ID: MGI:3804458
• Gene: Sox12 Location: Chr2:152235531-152239966 bp, - strand Genetic Position: Chr2, 74.94 cM
• Alliance: Sox12^tm1.1Weg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137911
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre-mediated recombination was used to remove the neo cassette and the open reading frame leaving the IRES-EGFP intact. The absence of transcript expression was confirmed by immunohistochemistry on brain sections. (J:137911)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox12 Mutation: 8 strains or lines available

References

• Original: J:137911 Hoser M, et al., Sox12 deletion in the mouse reveals nonreciprocal redundancy with the related Sox4 and Sox11 transcription factors. Mol Cell Biol. 2008 Aug;28(15):4675-87
• All: 1 reference(s)