Stx1b^tm1.1Sud
Targeted Allele Detail

Summary

• Symbol: Stx1b^tm1.1Sud
• Name: syntaxin 1B; targeted mutation 1.1, Thomas C Sudhof
• MGI ID: MGI:3804480
• Synonyms: syntaxin-1B^Open, XRB
• Gene: Stx1b Location: Chr7:127403072-127423703 bp, - strand Genetic Position: Chr7, 69.75 cM
• Alliance: Stx1b^tm1.1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138035
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Mice carrying the XTB allele were crossed to protamine-cre expressing animals and germ line cre-meditated excised the endogenous exon 7 carrying the GFP insert with the neomycin-selection cassette, leaving the mutated one behind. The resulting allele encodes the 'open' syntaxin-1B protein conformation. (J:138035)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Stx1b Mutation: 21 strains or lines available

References

• Original: J:138035 Gerber SH, et al., Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion. Science. 2008;321(5895):1507-10
• All: 3 reference(s)