Ppme1^tm1Crv
Targeted Allele Detail

Summary

• Symbol: Ppme1^tm1Crv
• Name: protein phosphatase methylesterase 1; targeted mutation 1, Benjamin J Cravatt
• MGI ID: MGI:3804708
• Synonyms: PME-1^-
• Gene: Ppme1 Location: Chr7:99975944-100021103 bp, - strand Genetic Position: Chr7, 54.35 cM, cytoband F1
• Alliance: Ppme1^tm1Crv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138002
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 7 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on brain, heart and liver extracts. (J:138002)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ppme1 Mutation: 24 strains or lines available

References

• Original: J:138002 Ortega-Gutierrez S, et al., Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice. PLoS One. 2008;3(7):e2486
• All: 4 reference(s)