Myod1^tm1Ahb
Targeted Allele Detail

Summary

• Symbol: Myod1^tm1Ahb
• Name: myogenic differentiation 1; targeted mutation 1, Annick Harel-Bellan
• MGI ID: MGI:3804837
• Synonyms: MyoD^R99,102
• Gene: Myod1 Location: Chr7:46025898-46028516 bp, + strand Genetic Position: Chr7, 30.03 cM
• Alliance: Myod1^tm1Ahb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116060
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Lysines 99 and 102 in the first exon were replaced by arginines. In addition, a floxed neo cassette used for selection that had been inserted in between exon 1 and 2, was removed via cre-mediated recombination. This mutation results in a non-acetylatable form of the protein. (J:116060)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myod1 Mutation: 23 strains or lines available

References

• Original: J:116060 Duquet A, et al., Acetylation is important for MyoD function in adult mice. EMBO Rep. 2006 Nov;7(11):1140-6
• All: 1 reference(s)