Wnt9btm1.2Amc
Targeted Allele Detail
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Symbol: |
Wnt9btm1.2Amc |
Name: |
wingless-type MMTV integration site family, member 9B; targeted mutation 1.2, Andrew P McMahon |
MGI ID: |
MGI:3805020 |
Synonyms: |
Wnt9bc, Wnt9bflox |
Gene: |
Wnt9b Location: Chr11:103618190-103640647 bp, - strand Genetic Position: Chr11, 67.47 cM
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Alliance: |
Wnt9btm1.2Amc page
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Germline Transmission: |
Earliest citation of germline transmission:
J:100575
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Parent Cell Line: |
AV3 (ES Cell)
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Strain of Origin: |
129X1/SvJ
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: A targeting vector was designed to insert a loxP site just upstream of exon 2, and a frt-flanked PGK-Neo cassette followed by a second loxP site just downstream of exon 2 of the targeted gene to generate Wnt9bMtm1Amc mice (Wnt9bcneo. To remove the frt-flanked selection cassette, these mice were then bred to an FLPe-expressing strain (on the Swiss-Webster genetic background). The resulting Wnt9bc offspring carry a loxP site just upstream of exon 2, and a single remaining frt-site followed by a second loxP site just downstream of exon 2.
(J:100575)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:100575 Carroll TJ, et al., Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell. 2005 Aug;9(2):283-92 |
All: |
7 reference(s) |
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