Tg(KRT14-VEGFC*)1Ali
Transgene Detail

Summary

• Symbol: Tg(KRT14-VEGFC*)1Ali
• Name: transgene insertion 1, Kari Alitalo
• MGI ID: MGI:3805119
• Synonyms: K14-VEGF-C156S
• Transgene: Tg(KRT14-VEGFC*)1Ali Location: unknown
• Alliance: Tg(KRT14-VEGFC*)1Ali page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT14-VEGFC*)1Ali expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  VEGFC (7424)

  Vegfc

  (MGI:109124)

• Mutation details: The human KRT14 promoter was used to drive expression of a mutant version of human VEGFC in which cysteine 156 is replaced with a serine. The mutant protein induces autophosphorylation of Flt4 but not Kdr. No line information was given. (J:68138)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:68138 Veikkola T, et al., Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice. EMBO J. 2001 Mar 15;20(6):1223-31
• All: 1 reference(s)