Ezh2^tm1.1Sho
Targeted Allele Detail

Summary

• Symbol: Ezh2^tm1.1Sho
• Name: enhancer of zeste 2 polycomb repressive complex 2 subunit; targeted mutation 1.1, Stuart Orkin
• MGI ID: MGI:3805309
• Synonyms: Ezh2^-
• Gene: Ezh2 Location: Chr6:47507073-47572275 bp, - strand Genetic Position: Chr6, 22.92 cM, cytoband B
• Alliance: Ezh2^tm1.1Sho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134477
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 16 and 17 containing part of the catalytic SET domain flanked by a set of loxP in Ezh2^tm1Sho were deleted. (J:134477)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ezh2 Mutation: 72 strains or lines available

References

• Original: J:134477 Puschendorf M, et al., PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nat Genet. 2008 Apr;40(4):411-20
• All: 1 reference(s)