Gt(ROSA)26Sor^{tm1(Rybp/EGFP)Cve}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Rybp/EGFP)Cve}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Ales Cvekel
• MGI ID: MGI:3805312
• Synonyms: ROSA26-RYBP/EGFP
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Rybp/EGFP)Cve} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134428
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutations: Insertion, Intragenic deletion
• Gt(ROSA)26Sor^{tm1(Rybp/EGFP)Cve} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Rybp (MGI:1929059)

• Mutation details: The gene locus was targeted with a floxed neo cassette followed by a Rybp/EGFP fusion gene. Mice carrying the allele do not express the fusion gene insert unless Cre recombinase first removes the neo cassette. Western blot analysis reveals expression of the fusion gene in cells exposed to Cre recombinase. (J:134428)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:134428 Pirity MK, et al., Rybp, a polycomb complex-associated protein, is required for mouse eye development. BMC Dev Biol. 2007;7:39
• All: 1 reference(s)