Gata2^{tm2(Gata2)Jeng}
Targeted Allele Detail

Summary

• Symbol: Gata2^{tm2(Gata2)Jeng}
• Name: GATA binding protein 2; targeted mutation 2, James Douglas Engel
• MGI ID: MGI:3805382
• Synonyms: Gata2^fGN
• Gene: Gata2 Location: Chr6:88170873-88184014 bp, + strand Genetic Position: Chr6, 39.2 cM
• Alliance: Gata2^{tm2(Gata2)Jeng} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138257
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Hypomorph, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Gata2^{tm2(Gata2)Jeng} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Gata2 (MGI:95662)

• Mutation details: Part of exon 2 was replaced with a full-length cDNA of the gene with a 5' loxP site followed by a floxed neo cassette. This allele is hypomorphic. (J:138257)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gata2 Mutation: 30 strains or lines available

References

• Original: J:138257 Hoshino T, et al., Reduced BMP4 abundance in Gata2 hypomorphic mutant mice result in uropathies resembling human CAKUT. Genes Cells. 2008 Feb;13(2):159-70
• All: 4 reference(s)