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Gata2tm2(Gata2)Jeng
Targeted Allele Detail
Summary
Symbol: Gata2tm2(Gata2)Jeng
Name: GATA binding protein 2; targeted mutation 2, James Douglas Engel
MGI ID: MGI:3805382
Synonyms: Gata2fGN
Gene: Gata2  Location: Chr6:88170873-88184014 bp, + strand  Genetic Position: Chr6, 39.2 cM
Alliance: Gata2tm2(Gata2)Jeng page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:138257
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Hypomorph, Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
 
Gata2tm2(Gata2)Jeng expresses 1 gene
 
Mutation detailsPart of exon 2 was replaced with a full-length cDNA of the gene with a 5' loxP site followed by a floxed neo cassette. This allele is hypomorphic. (J:138257)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gata2 Mutation:  30 strains or lines available
References
Original:  J:138257 Hoshino T, et al., Reduced BMP4 abundance in Gata2 hypomorphic mutant mice result in uropathies resembling human CAKUT. Genes Cells. 2008 Feb;13(2):159-70
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory