Col1a2^tm1Mcbr
Targeted Allele Detail

Summary

• Symbol: Col1a2^tm1Mcbr
• Name: collagen, type I, alpha 2; targeted mutation 1, Daniel McBride
• MGI ID: MGI:3805459
• Gene: Col1a2 Location: Chr6:4505618-4541543 bp, + strand Genetic Position: Chr6, 1.81 cM
• Alliance: Col1a2^tm1Mcbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178743
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 35 and a G to T mutation was inserted in exon 35 resulting in a glycine to cysteine mutation at codon 706. (J:178743)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col1a2 Mutation: 120 strains or lines available

References

• Original: J:178743 Daley E, et al., Variable bone fragility associated with an Amish COL1A2 variant and a knock-in mouse model. J Bone Miner Res. 2010 Feb;25(2):247-61
• All: 5 reference(s)