Sytl1^tm1Mitf
Targeted Allele Detail

Summary

• Symbol: Sytl1^tm1Mitf
• Name: synaptotagmin-like 1; targeted mutation 1, Mitsunori Fukuda
• MGI ID: MGI:3805583
• Synonyms: Slp1^-
• Gene: Sytl1 Location: Chr4:132980401-132990398 bp, - strand Genetic Position: Chr4, 66.25 cM
• Alliance: Sytl1^tm1Mitf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138210
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first coding exon was replaced with a neo cassette. This exon contains the translation initiation codon and encodes the Rab27 binding domain. The absence of protein expression was confirmed by western blot analysis on pancreas extracts. (J:138210)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sytl1 Mutation: 27 strains or lines available

References

• Original: J:138210 Saegusa C, et al., Expression of Rab27B-binding protein Slp1 in pancreatic acinar cells and its involvement in amylase secretion. Arch Biochem Biophys. 2008 Jul 1;475(1):87-92
• All: 3 reference(s)