Gpr22^tm1.1Jwad
Targeted Allele Detail

Summary

• Symbol: Gpr22^tm1.1Jwad
• Name: G protein-coupled receptor 22; targeted mutation 1.1, John W Adams
• MGI ID: MGI:3805680
• Gene: Gpr22 Location: Chr12:31756866-31763882 bp, - strand Genetic Position: Chr12, 13.69 cM
• Alliance: Gpr22^tm1.1Jwad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138227
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre-mediated recombination was used to remove the coding exon. The absence of transcript expression was confirmed by northern blot analysis on brain and heart extracts. (J:138227)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Gpr22^tm1.1Jwad/Gpr22^tm1.1Jwad	involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
cardiovascular system	√
increased response of heart to induced stress	√
homeostasis/metabolism	√
increased response of heart to induced stress	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr22 Mutation: 25 strains or lines available

References

• Original: J:138227 Adams JW, et al., Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor. Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H509-21
• All: 1 reference(s)