Card11^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Card11^m1Btlr
• Name: caspase recruitment domain family, member 11; mutation 1, Bruce Beutler
• MGI ID: MGI:3805728
• Synonyms: king
• Gene: Card11 Location: Chr5:140858745-140986337 bp, - strand Genetic Position: Chr5, 79.42 cM
• Alliance: Card11^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

Allele Type: Chemically induced (ENU) Mutation: Single point mutation Mutation details: This mutation was identified in a screen of G3 progeny of an ENU-mutagenized male mouse for developmental and/or functional CD8^+ T cell abnormalities. It comprises an A-to-T transversion at nucleotide position 1791 of the gene (Genbank Accession NM_175362.1) that is predicted to result in replacement of leucine by glutamine at amino acid position 525 of the 1159-amino acid protein (L525Q). Western blot analysis detects no CARD11 protein from the mutant allele in the spleen or lymph nodes, and thymic expression is reduced. (J:139069) Inheritance: Recessive

Genomic analysis of the Card11^m1Btlr allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Card11 Mutation: 59 strains or lines available

References

• Original: J:139069 Barnes MJ, et al., Record for "king". MGI Direct Data Submission. 2008
• All: 2 reference(s)