Igh^{tm1(Ighppc1-5)Cche}
Targeted Allele Detail

Summary

• Symbol: Igh^{tm1(Ighppc1-5)Cche}
• Name: immunoglobulin heavy chain complex; targeted mutation 1, Ching Chen
• MGI ID: MGI:3805804
• Synonyms: ppc1-5H
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138356
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A rearranged Igh VDJ segment, ppc1-5, was cloned from a natural autoantibody-producing hybridoma and inserted into the locus along with a neo cassette such that it replaced the JH segments. (J:138356)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 44 strains or lines available

References

• Original: J:138356 Tian Q, et al., B cells expressing a natural polyreactive autoantibody have a distinct phenotype and are overrepresented in immunoglobulin heavy chain transgenic mice. J Immunol. 2006 Aug 15;177(4):2412-22
• All: 2 reference(s)